| Cell line name |
HCT 116 SYT1 KO |
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| Accession |
CVCL_B3P8 |
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| Resource Identification Initiative |
To cite this cell line use: HCT 116 SYT1 KO (RRID:CVCL_B3P8) |
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| Comments |
From: Durcan, Thomas M.; Montreal Neurological Institute, McGill University; Montreal; Canada.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11509; SYT1.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0291 (HCT 116) |
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| Sex of cell |
Male |
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| Age at sampling |
48Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=39169954; DOI=10.12688/f1000research.154034.1; PMCID=PMC11336552
Biddle M.S., Alende C., Fotouhi M., Jones C., Ayoubi R., Southern K., Laflamme C., Virk H.ABIF ConsortiumNeuroSGC/YCharOS/EDDU Collaborative Group
A guide to selecting high-performing antibodies for synaptotagmin-1 (UniProt ID P21579) for use in western blot, immunoprecipitation, immunofluorescence and flow cytometry.
F1000Research 13:817.1-817.13(2024) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_B3P8
|
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| Encyclopedic resources |
Wikidata; Q110432846
|
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| Entry history |
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| Entry creation | 16-Dec-2021 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 8 |
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