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Cellosaurus HCC1954/TDR (CVCL_B3MM)

[Text version]
Cell line name HCC1954/TDR
Accession CVCL_B3MM
Resource Identification Initiative To cite this cell line use: HCC1954/TDR (RRID:CVCL_B3MM)
Comments Population: East Indian.
Selected for resistance to: DrugBank; DB05773; Trastuzumab emtansine (T-DM1).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene fusion; HGNC; 2092; CLTC + HGNC; 29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1259 (HCC1954)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line

Sabbaghi Mehrjardi M.A.
Uncovering mechanisms of acquired resistance to trastuzumab-emtansine (T-DM1) in HER2 positive breast cancer.
Thesis PhD (2017), Universitat de Barcelona, Spain

PubMed=28821558; DOI=10.1158/1078-0432.CCR-17-0696
Sabbaghi Mehrjardi M.A., Gil-Gomez G., Guardia C., Servitja S., Arpi O., Garcia-Alonso S., Menendez S., Arumi-Uria M., Serrano L., Salido M., Muntasell A., Martinez-Garcia M., Zazo S., Chamizo C., Gonzalez-Alonso P., Madoz-Gurpide J., Eroles P., Arribas J., Tusquets I., Lluch A., Pandiella A., Rojo F., Rovira A., Albanell J.
Defective cyclin B1 induction in trastuzumab-emtansine (T-DM1) acquired resistance in HER2-positive breast cancer.
Clin. Cancer Res. 23:7006-7019(2017)

Cell line databases/resources cancercelllines; CVCL_B3MM
Encyclopedic resources Wikidata; Q110432840
Entry history
Entry creation16-Dec-2021
Last entry update05-Oct-2023
Version number6