• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (PubMed=8790940).
  

DOI=10.11418/jtca1981.12.4_313
Namba M., Bai L., Kano Y., Sugihara S., Miyazaki M.
Multistep malignant transformation of human cells: immortalization of human fibroblasts by treatment with 60Co gamma rays and 4-nitroquinoline 1-oxide, and their malignant transformation with the ras oncogene.
Tissue Cult. Res. Commun. 12:313-318(1993)

PubMed=8148305
Namba M., Iijima M., Kondo T., Jahan I., Mihara K.
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Hum. Cell 6:253-259(1993)

PubMed=8428798; DOI=10.1002/ijc.2910530317
Bai L., Mihara K., Kondo Y., Honma M., Namba M.
Immortalization of normal human fibroblasts by treatment with 4-nitroquinoline 1-oxide.
Int. J. Cancer 53:451-456(1993)

PubMed=8557247; DOI=10.1007/BF00218823
Sugihara S., Mihara K., Marunouchi T., Inoue H., Namba M.
Telomere elongation observed in immortalized human fibroblasts by treatment with 60Co gamma rays or 4-nitroquinoline 1-oxide.
Hum. Genet. 97:1-6(1996)

PubMed=8744932; DOI=10.18926/AMO/30489
Iijima M., Kano Y., Nohno T., Namba M.
Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines.
Acta Med. Okayama 50:73-77(1996)

PubMed=8790940; DOI=10.1247/csf.21.111
Mihara K., Iijima M., Kondo T., Namba M.
Selective expression of mutated p53 in human cells immortalized with either 4-nitroquinoline 1-oxide or 60Co gamma rays.
Cell Struct. Funct. 21:111-116(1996)

DOI=10.11418/jtca1981.16.3_173
Mihara K., Miyazaki M., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-i., Ohashi R., Namba M.
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Tissue Cult. Res. Commun. 16:173-178(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9359923; DOI=10.18926/AMO/30789
Mihara K., Miyazaki M., Kondo T., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-i., Ishioka C., Namba M.
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Acta Med. Okayama 51:261-265(1997)