Cellosaurus logo
expasy logo

Cellosaurus NAN-3 (CVCL_B318)

[Text version]
Cell line name NAN-3
Synonyms NAN3
Accession CVCL_B318
Resource Identification Initiative To cite this cell line use: NAN-3 (RRID:CVCL_B318)
Comments Characteristics: Produces IgA kappa.
Characteristics: IL6 dependent.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Miscellaneous: Age at sampling and HLA typing from personal communication of Pellat-Deceunynck, Catherine.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248insGln (c.744insCAG); Zygosity=Unspecified (PubMed=21173094).
HLA typing Source: Direct_author_submission
Class I
HLA-AA*01,02
HLA-BB*08,40
HLA-CC*03,07
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

PubMed=16638930; DOI=10.1182/blood-2005-12-007971
Menoret E., Gomez-Bougie P., Geffroy-Luseau A., Daniels S., Moreau P., Le Gouill S., Harousseau J.-L., Bataille F.-R., Amiot M., Pellat-Deceunynck C.
Mcl-1L cleavage is involved in TRAIL-R1- and TRAIL-R2-mediated apoptosis induced by HGS-ETR1 and HGS-ETR2 human mAbs in myeloma cells.
Blood 108:1346-1352(2006)

PubMed=16956823
Bataille F.-R., Jego G., Robillard N., Barille-Nion S., Harousseau J.-L., Moreau P., Amiot M., Pellat-Deceunynck C.
The phenotype of normal, reactive and malignant plasma cells Identification of 'many and multiple myelomas' and of new targets for myeloma therapy.
Haematologica 91:1234-1240(2006)

PubMed=21173094; DOI=10.3324/haematol.2010.033456; PMCID=PMC3069235
Moreaux J., Klein B., Bataille F.-R., Descamps G., Maiga S., Hose D., Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M., Pellat-Deceunynck C.
A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
Haematologica 96:574-582(2011)

PubMed=30545397; DOI=10.1186/s13045-018-0679-0; PMCID=PMC6293660
Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S., Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M., Pellat-Deceunynck C.
Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
J. Hematol. Oncol. 11:137.1-137.13(2018)

Cross-references
Encyclopedic resources Wikidata; Q54907476
Gene expression databases ArrayExpress; E-TABM-1088
Polymorphism and mutation databases Cosmic; 2809780
IARC_TP53; 28516
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number18