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Cellosaurus RPC-9 (CVCL_B263)

[Text version]
Cell line name RPC-9
Synonyms RPC9
Accession CVCL_B263
Resource Identification Initiative To cite this cell line use: RPC-9 (RRID:CVCL_B263)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=17699786; DOI=10.1158/0008-5472.CAN-07-0681
Ogino A., Kitao H., Hirano S., Uchida A., Ishiai M., Kozuki T., Takigawa N., Takata M., Kiura K., Tanimoto M.
Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line.
Cancer Res. 67:7807-7814(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B263
Encyclopedic resources Wikidata; Q54951132
Polymorphism and mutation databases Cosmic; 1083085
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number20