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Cellosaurus Abcam K-562 ADAM17 KO (CVCL_B0ZA)

[Text version]
Cell line name Abcam K-562 ADAM17 KO
Synonyms Human ADAM17 knockout K562
Accession CVCL_B0ZA
Resource Identification Initiative To cite this cell line use: Abcam K-562 ADAM17 KO (RRID:CVCL_B0ZA)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 195; ADAM17.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Abcam; ab280045
Encyclopedic resources Wikidata; Q110432498
Entry history
Entry creation16-Dec-2021
Last entry update02-May-2024
Version number7