ID   MDA-MB-231br/eGFP
AC   CVCL_B0A0
DR   cancercelllines; CVCL_B0A0
DR   Wikidata; Q108820879
RX   PubMed=33264355;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Characteristics: Metastatic to brain. Established after injection of the parent cell line in the left ventricle of the heart of female nude mice and retrieving the brain metastatic cells and repeating this procedure 6 times.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A0YY ! MDA-MB-231br
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 05-10-23; Version: 6
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RX   PubMed=33264355; DOI=10.1371/journal.pone.0243156;
RA   De Meulenaere V., Descamps B., De Wever O., Vanhove C., Deblaere K.;
RT   "In vivo selection of the MDA-MB-231br/eGFP cancer cell line to obtain
RT   a clinically relevant rat model for triple negative breast cancer
RT   brain metastasis.";
RL   PLoS ONE 15:E0243156-E0243156(2020).
//