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Cellosaurus MeWo FOTE 4 (CVCL_AZ75)

[Text version]
Cell line name MeWo FOTE 4
Synonyms MeWo FOTE 4.0; MeWo-fotemustine 4
Accession CVCL_AZ75
Resource Identification Initiative To cite this cell line use: MeWo FOTE 4 (RRID:CVCL_AZ75)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_131848; Fotemustine (Mustophoran).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0445 (MeWo)
Sex of cell Male
Age at sampling 78Y
Category Cancer cell line
Publications

PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V
Grottke C., Mantwill K., Dietel M., Schadendorf D., Lage H.
Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.
Int. J. Cancer 88:535-546(2000)

PubMed=21475863; DOI=10.3892/mmr_00000134
Surowiak P., Drag M., Materna V., Dietel M., Lage H.
Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines.
Mol. Med. Rep. 2:543-548(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AZ75
Encyclopedic resources Wikidata; Q54905341
Entry history
Entry creation02-May-2016
Last entry update19-Dec-2024
Version number14