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Cellosaurus MeWo CIS 0.01 (CVCL_AZ60)

[Text version]
Cell line name MeWo CIS 0.01
Synonyms MeWo-cisplatin 0.01
Accession CVCL_AZ60
Resource Identification Initiative To cite this cell line use: MeWo CIS 0.01 (RRID:CVCL_AZ60)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Proteome analysis by 2D-DE.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0445 (MeWo)
Sex of cell Male
Age at sampling 78Y
Category Cancer cell line
Publications

PubMed=11001322; DOI=10.1002/1522-2683(20000801)21:14<3048::AID-ELPS3048>3.0.CO;2-W
Sinha P., Kohl S., Fischer J., Hutter G., Kern M., Kottgen E., Dietel M., Lage H., Schnolzer M., Schadendorf D.
Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis.
Electrophoresis 21:3048-3057(2000)

PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V
Grottke C., Mantwill K., Dietel M., Schadendorf D., Lage H.
Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.
Int. J. Cancer 88:535-546(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AZ60
Encyclopedic resources Wikidata; Q54905337
Entry history
Entry creation02-May-2016
Last entry update19-Dec-2024
Version number14