Cellosaurus cell line S520 (CVCL

Cellosaurus S520 (CVCL_AX35)

Cross-references
Cell line name	S520
Synonyms	Patient 2 cell line
Accession	CVCL_AX35
Resource Identification Initiative	To cite this cell line use: S520 (RRID:CVCL_AX35)
Comments	Derived from site: In situ; Shoulder; UBERON=UBERON_0001467.
Sequence variations	Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (PubMed=15207265). Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=15207265). Mutation; HGNC; HGNC:7765; NF1; Simple; p.Arg440Ter (c.1318C>T); ClinVar=VCV000230673; Zygosity=Heterozygous (PubMed=15207265).
Disease	Malignant peripheral nerve sheath tumor (NCIt: C3798) Neurofibromatosis type 1 (NCIt: C3273) Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148) Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	35Y
Category	Cancer cell line
Publications	PubMed=15207265; DOI=10.1016/j.nbd.2004.01.006 Frahm S., Mautner V.-F., Brems H., Legius E., Debiec-Rychter M., Friedrich R.E., Knoefel W.T., Peiper M., Kluwe L. Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients. Neurobiol. Dis. 16:85-91(2004) PubMed=15735744; DOI=10.1038/sj.onc.1208425 Mashour G.A., Drissel S.N., Frahm S., Farassati F., Martuza R.L., Mautner V.-F., Kindler-Rohrborn A., Kurtz A. Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids. Oncogene 24:2367-2374(2005) PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054 Pemov A., Li H., Presley W., Wallace M.R., Miller D.T. Genetics of human malignant peripheral nerve sheath tumors. Neurooncol. Adv. 2:i50-i61(2020)
Cell line databases/resources	cancercelllines; CVCL_AX35
Encyclopedic resources	Wikidata; Q54951957
Polymorphism and mutation databases	Cosmic; 1801810
Entry history
Entry creation	02-May-2016
Last entry update	19-Dec-2024
Version number	10