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Cellosaurus MDA-1686 (CVCL_AT79)

[Text version]
Cell line name MDA-1686
Synonyms MDA 1686; MDA1686
Accession CVCL_AT79
Resource Identification Initiative To cite this cell line use: MDA-1686 (RRID:CVCL_AT79)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218Gly (c.653T>G); ClinVar=VCV000528249; Zygosity=Unspecified (PubMed=7927946).
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr256Hisfs*89 (c.766delA); Zygosity=Unspecified (PubMed=7927946).
Disease Oral cavity squamous cell carcinoma (NCIt: C4833)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO12
D5S81813
D7S8208,11
D13S3178,12
D16S53912,13
TH017,10
TPOX8
vWA14,16

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=7927946; DOI=10.1002/ijc.2910590316
Xu L., Davidson B.J., Murty V.V.V.S., Li R.-G., Sacks P.G., Garin-Chesa P., Schantz S.P., Chaganti R.S.K.
TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines.
Int. J. Cancer 59:383-387(1994)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AT79
Encyclopedic resources Wikidata; Q54904556
Polymorphism and mutation databases Cosmic; 2131851
IARC_TP53; 3549
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number12