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Cellosaurus DU145/RC0.1 (CVCL_AS75)

[Text version]
Cell line name DU145/RC0.1
Synonyms DU145 RC0.1; RC0.1; RCO.1; RC01
Accession CVCL_AS75
Resource Identification Initiative To cite this cell line use: DU145/RC0.1 (RRID:CVCL_AS75)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11986; TOP1; Simple; p.Arg364His (c.1091G>A); Zygosity=Homozygous (PubMed=11280753).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): PubMed=19372543


Run an STR similarity search on this cell line

Urasaki Y., Laco G.S., Pourquier P., Takebayashi Y., Kohlhagen G., Gioffre C., Zhang H.-L., Chatterjee D., Pantazis P., Pommier Y.
Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.
Cancer Res. 61:1964-1969(2001)

Reinhold W.C., Kouros-Mehr H., Kohn K.W., Maunakea A.K., Lababidi S., Roschke A.V., Stover K., Alexander J., Pantazis P., Miller L., Liu E.T., Kirsch I.R., Urasaki Y., Pommier Y., Weinstein J.N.
Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping.
Cancer Res. 63:1000-1011(2003)

PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921
Lorenzi P.L., Reinhold W.C., Varma S., Hutchinson A.A., Pommier Y., Chanock S.J., Weinstein J.N.
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)

PubMed=22347499; DOI=10.1371/journal.pone.0031628
Ruan X.-Y., Kocher J.-P.A., Pommier Y., Liu H.-F., Reinhold W.C.
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:E31628-E31628(2012)

PubMed=24670534; DOI=10.1371/journal.pone.0092047
Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C.
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:E92047-E92047(2014)

Cell line databases/resources cancercelllines; CVCL_AS75
Encyclopedic resources Wikidata; Q54831575
Gene expression databases GEO; GSM750772
GEO; GSM799380
GEO; GSM799443
GEO; GSM1153443
GEO; GSM1181318
GEO; GSM1181329
Polymorphism and mutation databases Progenetix; CVCL_AS75
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number16