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Cellosaurus 786-O/Luc (CVCL_AS74)

[Text version]
Cell line name 786-O/Luc
Synonyms 786-0/Luciferase
Accession CVCL_AS74
Resource Identification Initiative To cite this cell line use: 786-O/Luc (RRID:CVCL_AS74)
Comments Population: Caucasian.
Characteristics: Expression of luciferase is under the control of the CMV promoter.
Transfected with: UniProtKB; P08659; Firefly luciferase (pRev_CMV_Luc2).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.560-2A>G; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1051 (786-O)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line

PubMed=20443133; DOI=10.1007/s10585-010-9329-9
Strube A., Stepina E., Mumberg D., Scholz A., Hauff P., Kakonen S.-M.
Characterization of a new renal cell carcinoma bone metastasis mouse model.
Clin. Exp. Metastasis 27:319-330(2010)

Cell line databases/resources cancercelllines; CVCL_AS74
Encyclopedic resources Wikidata; Q54604953
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number16