ID   TK6 (IVGT)
AC   CVCL_AR68
SY   TK6(IVGT)
DR   ECACC; 13051501
DR   GEO; GSM4288410
DR   JCRB; JCRB1435
DR   Wikidata; Q54972536
RX   PubMed=27692294;
RX   PubMed=29892436;
RX   PubMed=33198927;
CC   Part of: In Vitro Genetic Toxicity (IVGT) cell line panel.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
CC   Sequence variation: Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (PubMed=33198927).
CC   Sequence variation: Mutation; HGNC; 11830; TK1; Simple; p.Ala78Argfs*27 (c.231insC); Zygosity=Heterozygous (PubMed=33198927).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
ST   Source(s): ECACC=13051501; JCRB=JCRB1435
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D5S818: 12,13
ST   D7S820: 9,11
ST   TH01: 8,9.3
ST   TPOX: 8,11
ST   vWA: 17,20
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0561 ! TK6
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 02-05-16; Last updated: 02-05-24; Version: 13
//
RX   PubMed=27692294; DOI=10.1016/j.mrgentox.2016.08.001;
RA   Lorge E., Moore M.M., Clements J., O'Donovan M., Fellows M.D., Honma M.,
RA   Kohara A., Galloway S., Armstrong M.J., Thybaud V., Gollapudi B.,
RA   Aardema M.J., Tanir J.Y.;
RT   "Standardized cell sources and recommendations for good cell culture
RT   practices in genotoxicity testing.";
RL   Mutat. Res. 809:1-15(2016).
//
RX   PubMed=29892436; DOI=10.1098/rsos.172472;
RA   Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M.,
RA   Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S.,
RA   Satoh M., Shimizu N., Kohara A.;
RT   "Screening for 15 pathogenic viruses in human cell lines registered at
RT   the JCRB Cell Bank: characterization of in vitro human cells by viral
RT   infection.";
RL   R. Soc. Open Sci. 5:172472-172472(2018).
//
RX   PubMed=33198927; DOI=10.1016/j.mrgentox.2020.503236;
RA   Kasai F., Hirayama N., Kohara A.;
RT   "TK6 genome profile compared with WIL2-NS: reference data to improve
RT   the reproducibility of genotoxicity studies.";
RL   Mutat. Res. 858:503236.1-503236.7(2020).
//