Cellosaurus cell line Lymph2-AD2-iPS (CVCL

Cross-references
Cell line name	Lymph2-AD2-iPS
Synonyms	AD2-2 iPSC
Accession	CVCL_AB84
Resource Identification Initiative	To cite this cell line use: Lymph2-AD2-iPS (RRID:CVCL_AB84)
Comments	From: Heinrich-Heine-Universitat Dusseldorf; Dusseldorf; Germany. Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Mutation; HGNC; HGNC:17761; TREM2; Simple; p.Arg47His (c.140G>A); ClinVar=VCV000195350; Zygosity=Heterozygous (PubMed=27345793).
Disease	Alzheimer's disease 17 (NCIt: C169104) Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	65Y
Category	Induced pluripotent stem cell
Publications	PubMed=27345793; DOI=10.1016/j.scr.2015.12.017 Schroter F., Sleegers K., Cuyvers E., Bohndorf M., Wruck W., Van Broeckhoven C., Adjaye J. Lymphoblast-derived integration-free iPS cell line from a 65-year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Stem Cell Res. 16:113-115(2016)
Cell line databases/resources	SKIP; SKIP003221
Encyclopedic resources	Wikidata; Q54903366
Entry history
Entry creation	23-Feb-2016
Last entry update	19-Dec-2024
Version number	13