ID   HHT4
AC   CVCL_A9Z1
SY   HHT-4
DR   Wikidata; Q102114125
RX   PubMed=17404395;
RX   PubMed=20017137;
RX   PubMed=32899426;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Hepatocyte; CL=CL_0000182.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Adult
CA   Telomerase immortalized cell line
DT   Created: 29-10-20; Last updated: 10-04-25; Version: 8
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RX   PubMed=17404395; DOI=10.1093/carcin/bgm075;
RA   Budhu A., Chen Y., Kim J.W., Forgues M., Valerie K., Harris C.C.,
RA   Wang X.-W.;
RT   "Induction of a unique gene expression profile in primary human
RT   hepatocytes by hepatitis C virus core, NS3 and NS5A proteins.";
RL   Carcinogenesis 28:1552-1560(2007).
//
RX   PubMed=20017137; DOI=10.1002/ijc.25118; PMCID=PMC2950321;
RA   Jiang W.-D., Wang X.-W., Unger T., Forgues M., Kim J.W., Hussain S.P.,
RA   Bowman E., Spillare E.A., Lipsky M.M., Meck J.M., Cavalli L.R.,
RA   Haddad B.R., Harris C.C.;
RT   "Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in
RT   regulating cell proliferation, anchorage-independent growth and
RT   aneuploidy in a telomerase-immortalized normal human
RT   hepatocyte-derived cell line.";
RL   Int. J. Cancer 127:1011-1020(2010).
//
RX   PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451;
RA   Scherer D., Davila-Lopez M., Goeppert B., Abrahamsson S.,
RA   Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D.,
RA   Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.;
RT   "RNA sequencing of hepatobiliary cancer cell lines: data and
RT   applications to mutational and transcriptomic profiling.";
RL   Cancers (Basel) 12:2510.1-2510.14(2020).
//