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Cellosaurus CTSC#383 (CVCL_A9WM)

[Text version]
Cell line name CTSC#383
Synonyms CRC-SC#383
Accession CVCL_A9WM
Resource Identification Initiative To cite this cell line use: CTSC#383 (RRID:CVCL_A9WM)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Stable (MSS) (PubMed=33128777).
Derived from site: In situ; Colon, distal; UBERON=UBERON_0008971.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Arg564Ter (c.1690C>T); ClinVar=VCV000000808; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Ala612Hisfs*18 (c.1834delG); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Trp690Arg (c.2068T>C); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Asp54Tyr (c.160G>T); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV000197243; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Glu326Lys (c.976G>A); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Asn (c.644G>A); ClinVar=VCV000376662; Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812
D7S82011,12
D13S3179,11
D16S53912,15
TH019,9.3
TPOX9,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=27286453; DOI=10.18632/oncotarget.9859; PMCID=PMC5190083
Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget 7:44113-44128(2016)

PubMed=33128777; DOI=10.1002/ijc.33370; PMCID=PMC7894552
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WM
Encyclopedic resources Wikidata; Q102113739
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number8