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Cellosaurus CTSC#18 (CVCL_A9WJ)

[Text version]
Cell line name CTSC#18
Synonyms CRC-SC#18
Accession CVCL_A9WJ
Resource Identification Initiative To cite this cell line use: CTSC#18 (RRID:CVCL_A9WJ)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Instable (MSI-high) (PubMed=33128777).
Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972.
Sequence variations
  • Mutation; HGNC; HGNC:172; ACVR1B; Simple; p.Trp501Ter (c.1503G>A); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Ala199Val (c.596C>T); ClinVar=VCV000246301; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gly2250Asp (c.6749G>A); ClinVar=VCV001502413; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Lys647Glu (c.1939A>G); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn323Metfs*21 (c.968delA); ClinVar=VCV000653412; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:11641; TCF7L2; Simple; p.Ser569Profs*33 (c.1700delC); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp148Ter (c.441dupT); Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX
CSF1PO9,14
D5S81811,12
D7S82010,13
D13S31711,12
D16S53911
TH016,9.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=27286453; DOI=10.18632/oncotarget.9859; PMCID=PMC5190083
Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget 7:44113-44128(2016)

PubMed=33128777; DOI=10.1002/ijc.33370; PMCID=PMC7894552
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WJ
Encyclopedic resources Wikidata; Q102113738
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number9