ID   Rev-CEM-E7
AC   CVCL_A9NR
SY   RevCEM-E7; RevCEM clone E7
DR   BEI_Resources; ARP-13435
DR   cancercelllines; CVCL_A9NR
DR   Wikidata; Q108821221
RX   PubMed=27812216;
CC   Population: Caucasian.
CC   Characteristics: Transfected with a pNL-GFP-RRE(SA) construct that results in the expression of the GFP gene under the control of the HIV-1 LTR promoter in HIV-1 infected cells when Tat and Rev are present.
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1E04 ! Rev-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 19-12-24; Version: 9
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RX   PubMed=27812216; DOI=10.1371/journal.ppat.1005964; PMCID=PMC5094736;
RA   Boulle M., Muller T.G., Dahling S., Ganga Y., Jackson L., Mahamed D.,
RA   Oom L., Lustig G., Neher R.A., Sigal A.;
RT   "HIV cell-to-cell spread results in earlier onset of viral gene
RT   expression by multiple infections per cell.";
RL   PLoS Pathog. 12:E1005964-E1005964(2016).
//