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Cellosaurus Rev-CEM-D4 (CVCL_A9NQ)

[Text version]
Cell line name Rev-CEM-D4
Synonyms RevCEM-D4; RevCEM clone D4
Accession CVCL_A9NQ
Resource Identification Initiative To cite this cell line use: Rev-CEM-D4 (RRID:CVCL_A9NQ)
Comments Population: Caucasian.
Characteristics: Transfected with a pNL-GFP-RRE(SA) construct that results in the expression of the GFP gene under the control of the HIV-1 LTR promoter in HIV-1 infected cells when Tat and Rev are present.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1E04 (Rev-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Cross-references
Cell line collections (Providers) BEI_Resources; ARP-13437
Cell line databases/resources cancercelllines; CVCL_A9NQ
Encyclopedic resources Wikidata; Q108821220
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number9