ID   GIST-T1/816
AC   CVCL_A9N0
DR   cancercelllines; CVCL_A9N0
DR   GEO; GSM2527258
DR   GEO; GSM2527259
DR   Wikidata; Q102113881
RX   PubMed=25239608;
RX   PubMed=29866822;
RX   PubMed=32736695;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (PubMed=25239608).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Asp820Glu (c.2460T>A) (D816E); ClinVar=VCV000375929; Zygosity=Heterozygous (PubMed=25239608).
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Interstitial cell of Cajal; CL=CL_0002088.
DI   NCIt; C3868; Gastrointestinal stromal tumor
DI   ORDO; Orphanet_44890; Gastrointestinal stromal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4976 ! GIST-T1
SX   Female
AG   47Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 30-01-24; Version: 7
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RX   PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397;
RA   Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J.,
RA   Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y.,
RA   Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C.,
RA   Fletcher J.A., Bauer S., Rivera V.M.;
RT   "Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and
RT   shows therapeutic potential in heavily pretreated gastrointestinal
RT   stromal tumor (GIST) patients.";
RL   Clin. Cancer Res. 20:5745-5755(2014).
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RX   PubMed=29866822; DOI=10.1073/pnas.1802079115;
RA   Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A.,
RA   Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D.,
RA   Bradner J.E.;
RT   "Gastrointestinal stromal tumor enhancers support a transcription
RT   factor network predictive of clinical outcome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018).
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RX   PubMed=32736695; DOI=10.1016/j.bbrc.2020.05.174;
RA   Cho W.-C., Shin Y.-K., Na Y.-S., Ryu M.-H., Ku J.-L., Kang Y.-K.;
RT   "The role of novel fusion genes in human GIST cell lines derived from
RT   imatinib-resistant GIST patients: a therapeutic potential of fusion
RT   gene.";
RL   Biochem. Biophys. Res. Commun. 529:699-706(2020).
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