ID   GIST-T1/670
AC   CVCL_A9M9
SY   GIST-T1 T670I; GIST-5R
DR   cancercelllines; CVCL_A9M9
DR   Cosmic; 2805391
DR   Wikidata; Q102113880
RX   PubMed=25239608;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (PubMed=25239608).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Thr670Ile (c.2009C>T); ClinVar=VCV000376058; Zygosity=Heterozygous (PubMed=25239608).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Interstitial cell of Cajal; CL=CL_0002088.
DI   NCIt; C3868; Gastrointestinal stromal tumor
DI   ORDO; Orphanet_44890; Gastrointestinal stromal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4976 ! GIST-T1
SX   Female
AG   47Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 19-12-24; Version: 8
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RX   PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397; PMCID=PMC4233175;
RA   Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J.,
RA   Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y.,
RA   Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C.,
RA   Fletcher J.A., Bauer S., Rivera V.M.;
RT   "Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and
RT   shows therapeutic potential in heavily pretreated gastrointestinal
RT   stromal tumor (GIST) patients.";
RL   Clin. Cancer Res. 20:5745-5755(2014).
//