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Cellosaurus GIST226 (CVCL_A9M8)

[Text version]
Cell line name GIST226
Synonyms GIST-226
Accession CVCL_A9M8
Resource Identification Initiative To cite this cell line use: GIST226 (RRID:CVCL_A9M8)
Comments Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Lys550_Trp557del (c.1648_1671del); Zygosity=Heterozygous (PubMed=29866822).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Tyr823Asp (c.2467T>G); ClinVar=VCV000376101; Zygosity=Heterozygous (PubMed=29866822).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397; PMCID=PMC4233175
Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J., Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y., Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C., Fletcher J.A., Bauer S., Rivera V.M.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin. Cancer Res. 20:5745-5755(2014)

PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782
Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A., Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D., Bradner J.E.
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9M8
Encyclopedic resources Wikidata; Q102113882
Gene expression databases GEO; GSM2527264
GEO; GSM2527265
GEO; GSM2786734
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number7