Cellosaurus cell line Ecad-231-7 (CVCL

Cellosaurus Ecad-231-7 (CVCL_A9BP)

Cross-references
Cell line name	Ecad-231-7
Synonyms	Ecad231-7
Accession	CVCL_A9BP
Resource Identification Initiative	To cite this cell line use: Ecad-231-7 (RRID:CVCL_A9BP)
Comments	Group: Triple negative breast cancer (TNBC) cell line. Population: Caucasian. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1748; CDH1. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease	Breast adenocarcinoma (NCIt: C5214)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0062 (MDA-MB-231)
Sex of cell	Female
Age at sampling	51Y
Category	Cancer cell line
Publications	PubMed=21215101; DOI=10.3760/cma.j.issn.0529-5807.2010.12.011 Yang L.-J., Liu Y.-Q., Gu B., Bian X.-C., Feng H.-L., Yang Z.-L., Liu Y.-Y. Effect of forced E-cadherin expression on adhesion and proliferation of human breast carcinoma cells. Zhonghua Bing Li Xue Za Zhi 39:842-847(2010)
Cell line databases/resources	cancercelllines; CVCL_A9BP CCRID; 1101HUM-PUMC000398
Encyclopedic resources	Wikidata; Q108820180
Entry history
Entry creation	23-Sep-2021
Last entry update	19-Dec-2024
Version number	8