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Cellosaurus LT97 (CVCL_A9BJ)

[Text version]
Cell line name LT97
Synonyms LT97-1
Accession CVCL_A9BJ
Resource Identification Initiative To cite this cell line use: LT97 (RRID:CVCL_A9BJ)
Comments Characteristics: Contains 2 subpopulations of cells, one CD44+, the other CD44- (PubMed=17708598).
Doubling time: ~96 hours (DOI=10.25365/thesis.6275).
Miscellaneous: STR profile mentioned in PubMed=27996158 but obtained from personal communication of Schlormann, Wiebke.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
Disease Colorectal adenoma (NCIt: C5673)
Familial adenomatous polyposis (NCIt: C3339)
Familial adenomatous polyposis (ORDO: Orphanet_733)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D5XV (LT97-2)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27996158

Markers:
AmelogeninX
CSF1PO8,11
D5S81811
D7S8208,12
D13S31711,13
D16S53911
TH017,9.3
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=12204677; DOI=10.1016/S0959-8049(02)00158-2
Richter M., Jurek D., Wrba F., Kaserer K., Wurzer G., Karner-Hanusch J., Marian B.
Cells obtained from colorectal microadenomas mirror early premalignant growth patterns in vitro.
Eur. J. Cancer 38:1937-1945(2002)

PubMed=12714179; DOI=10.1016/S0027-5107(03)00012-5
Schaeferhenrich A., Beyer-Sehlmeyer G., Festag G., Kuechler A., Haag N., Weise A., Liehr T., Claussen U., Marian B., Sendt W., Scheele J., Pool-Zobel B.L.
Human adenoma cells are highly susceptible to the genotoxic action of 4-hydroxy-2-nonenal.
Mutat. Res. 526:19-32(2003)

PubMed=17708598; DOI=10.1002/path.2220
Schulenburg A., Cech P., Herbacek I., Marian B., Wrba F., Valent P., Ulrich-Pur H.
CD44-positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2).
J. Pathol. 213:152-160(2007)

DOI=10.25365/thesis.6275
Koneczny I.
Investigating a model cell line for tumour stem cells in colorectal cancer.
Thesis MSc (2009); University of Vienna; Vienna; Austria

PubMed=27996158; DOI=10.1002/mc.22606
Schlormann W., Lamberty J., Lorkowski S., Ludwig D., Mothes H., Saupe C., Glei M.
Chemopreventive potential of in vitro fermented nuts in LT97 colon adenoma and primary epithelial colon cells.
Mol. Carcinog. 56:1461-1471(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9BJ
Encyclopedic resources Wikidata; Q108820805
Polymorphism and mutation databases IARC_TP53; 25023
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number9