ID   HOS-SL
AC   CVCL_A9AN
DR   cancercelllines; CVCL_A9AN
DR   IARC_TP53; 230
DR   Wikidata; Q108820494
RX   PubMed=2531855;
RX   PubMed=2978869;
CC   Population: Caucasian.
CC   Characteristics: Non-tumorigenic.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (PubMed=2531855).
CC   Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
CC   Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2544 ! KHOS-240S
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 05-10-23; Version: 5
//
RX   PubMed=2531855;
RA   Romano J.W., Ehrhart J.-C., Duthu A., Kim C.M., Appella E., May P.;
RT   "Identification and characterization of a p53 gene mutation in a human
RT   osteosarcoma cell line.";
RL   Oncogene 4:1483-1488(1989).
//
RX   PubMed=2978869;
RA   Ehrhart J.-C., Duthu A., Ullrich S., Appella E., May P.;
RT   "Specific interaction between a subset of the p53 protein family and
RT   heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line.";
RL   Oncogene 3:595-603(1988).
//