ID   BCK4
AC   CVCL_A9A5
SY   BCK-4
DR   GEO; GSE101742
DR   Wikidata; Q102113608
RX   PubMed=23247610;
RX   PubMed=25757734;
RX   PubMed=27565181;
RX   PubMed=29176653;
RX   PubMed=30228172;
RX   PubMed=30317423;
CC   Characteristics: ER-positive, PR-positive and ERBB2-negative. Has mucinous features. Established from a mouse xenograft.
CC   Doubling time: ~120 hours (PubMed=23247610).
CC   Omics: Transcriptomics; Microarray.
CC   Miscellaneous: STR profile from personal communication of Atkinson, Jennifer M.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12,13
ST   D16S539: 13
ST   D18S51: 13,14
ST   D21S11: 30,30.2
ST   D3S1358: 14,15
ST   D5S818: 11,12
ST   D7S820: 9,11
ST   D8S1179: 12,16
ST   FGA: 21,24
ST   Penta D: 10,13
ST   Penta E: 7,13
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C7950; Invasive breast lobular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   65Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 10-04-25; Version: 8
//
RX   PubMed=30317423; DOI=10.1007/s10549-018-4989-2; PMCID=PMC6813790;
RA   Astashchanka, Anna
RA   Shroka, Thomas M.
RA   Jacobsen, Britta M.
RT   "Mucin 2 (MUC2) modulates the aggressiveness of breast cancer.";
RL   Breast Cancer Res. Treat. 173:289-299(2019).
//
RX   PubMed=23247610; DOI=10.1007/s10549-012-2377-x; PMCID=PMC3543987;
RA   Jambal, Purevsuren
RA   Badtke, Melanie M.
RA   Harrell, J. Chuck
RA   Borges, Virginia F.
RA   Post, Miriam Denise
RA   Sollender, Grace Elizabeth
RA   Spillman, Monique Ann
RA   Horwitz, Kathryn Bloch
RA   Jacobsen, Britta M.
RT   "Estrogen switches pure mucinous breast cancer to invasive lobular
RT   carcinoma with mucinous features.";
RL   Breast Cancer Res. Treat. 137:431-448(2013).
//
RX   PubMed=29176653; DOI=10.1038/s41389-017-0002-x; PMCID=PMC5868054;
RA   Harrell, J. Chuck
RA   Shroka, Thomas M.
RA   Jacobsen, Britta M.
RT   "Estrogen induces c-Kit and an aggressive phenotype in a model of
RT   invasive lobular breast cancer.";
RL   Oncogenesis 6:396.1-396.16(2017).
//
RX   PubMed=27565181; DOI=10.1158/1541-7786.MCR-16-0167; PMCID=PMC5107172;
RA   D'Amato, Nicholas C.
RA   Gordon, Michael A.
RA   Babbs, Beatrice
RA   Spoelstra, Nicole S.
RA   Carson Butterfield, Kiel T.
RA   Torkko, Kathleen C.
RA   Phan, Vernon T.
RA   Barton, Valerie N.
RA   Rogers, Thomas J.
RA   Sartorius, Carol A.
RA   Elias, Anthony David
RA   Gertz, Jason
RA   Jacobsen, Britta M.
RA   Richer, Jennifer K.
RT   "Cooperative dynamics of AR and ER activity in breast cancer.";
RL   Mol. Cancer Res. 14:1054-1067(2016).
//
RX   PubMed=30228172; DOI=10.1158/0008-5472.CAN-18-1416; PMCID=PMC6507416;
RA   Tasdemir, Nilgun
RA   Bossart, Emily Ann
RA   Li, Zhe-Qi
RA   Zhu, Li
RA   Sikora, Matthew J.
RA   Levine, Kevin M.
RA   Jacobsen, Britta M.
RA   Tseng, George Chien-Cheng
RA   Davidson, Nancy E.
RA   Oesterreich, Steffi
RT   "Comprehensive phenotypic characterization of human invasive lobular
RT   carcinoma cell lines in 2D and 3D cultures.";
RL   Cancer Res. 78:6209-6222(2018).
//
RX   PubMed=25757734; DOI=10.1186/s13058-015-0517-z; PMCID=PMC4320436;
RA   Christgen, Matthias
RA   Derksen, Patrick W.B.
RT   "Lobular breast cancer: molecular basis, mouse and cellular models.";
RL   Breast Cancer Res. 17:16.1-16.9(2015).
//