ID   BCK4
AC   CVCL_A9A5
SY   BCK-4
DR   GEO; GSE101742
DR   Wikidata; Q102113608
RX   PubMed=23247610;
RX   PubMed=25757734;
RX   PubMed=27565181;
RX   PubMed=29176653;
RX   PubMed=30228172;
RX   PubMed=30317423;
CC   Characteristics: ER-positive, PR-positive and ERBB2-negative. Has mucinous features. Established from a mouse xenograft.
CC   Doubling time: ~120 hours (PubMed=23247610).
CC   Omics: Transcriptome analysis by microarray.
CC   Miscellaneous: STR profile from personal communication of Atkinson, Jennifer M.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12,13
ST   D16S539: 13
ST   D18S51: 13,14
ST   D21S11: 30,30.2
ST   D3S1358: 14,15
ST   D5S818: 11,12
ST   D7S820: 9,11
ST   D8S1179: 12,16
ST   FGA: 21,24
ST   Penta D: 10,13
ST   Penta E: 7,13
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C7950; Invasive breast lobular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   65Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 10-09-24; Version: 7
//
RX   PubMed=23247610; DOI=10.1007/s10549-012-2377-x; PMCID=PMC3543987;
RA   Jambal P., Badtke M.M., Harrell J.C., Borges V.F., Post M.D.,
RA   Sollender G.E., Spillman M.A., Horwitz K.B., Jacobsen B.M.;
RT   "Estrogen switches pure mucinous breast cancer to invasive lobular
RT   carcinoma with mucinous features.";
RL   Breast Cancer Res. Treat. 137:431-448(2013).
//
RX   PubMed=25757734; DOI=10.1186/s13058-015-0517-z; PMCID=PMC4320436;
RA   Christgen M., Derksen P.W.B.;
RT   "Lobular breast cancer: molecular basis, mouse and cellular models.";
RL   Breast Cancer Res. 17:16.1-16.9(2015).
//
RX   PubMed=27565181; DOI=10.1158/1541-7786.MCR-16-0167; PMCID=PMC5107172;
RA   D'Amato N.C., Gordon M.A., Babbs B., Spoelstra N.S.,
RA   Carson Butterfield K.T., Torkko K.C., Phan V.T., Barton V.N.,
RA   Rogers T.J., Sartorius C.A., Elias A.D., Gertz J., Jacobsen B.M.,
RA   Richer J.K.;
RT   "Cooperative dynamics of AR and ER activity in breast cancer.";
RL   Mol. Cancer Res. 14:1054-1067(2016).
//
RX   PubMed=29176653; DOI=10.1038/s41389-017-0002-x; PMCID=PMC5868054;
RA   Harrell J.C., Shroka T.M., Jacobsen B.M.;
RT   "Estrogen induces c-Kit and an aggressive phenotype in a model of
RT   invasive lobular breast cancer.";
RL   Oncogenesis 6:396.1-396.16(2017).
//
RX   PubMed=30228172; DOI=10.1158/0008-5472.CAN-18-1416; PMCID=PMC6507416;
RA   Tasdemir N., Bossart E.A., Li Z.-Q., Zhu L., Sikora M.J., Levine K.M.,
RA   Jacobsen B.M., Tseng G.C.-C., Davidson N.E., Oesterreich S.;
RT   "Comprehensive phenotypic characterization of human invasive lobular
RT   carcinoma cell lines in 2D and 3D cultures.";
RL   Cancer Res. 78:6209-6222(2018).
//
RX   PubMed=30317423; DOI=10.1007/s10549-018-4989-2; PMCID=PMC6813790;
RA   Astashchanka A., Shroka T.M., Jacobsen B.M.;
RT   "Mucin 2 (MUC2) modulates the aggressiveness of breast cancer.";
RL   Breast Cancer Res. Treat. 173:289-299(2019).
//