Cellosaurus cell line SJ-GBM5 (CVCL

Cellosaurus SJ-GBM5 (CVCL_A8SE)

Cross-references
Cell line name	SJ-GBM5
Synonyms	SJ-G5
Accession	CVCL_A8SE
Resource Identification Initiative	To cite this cell line use: SJ-GBM5 (RRID:CVCL_A8SE)
Comments	Senescence: Undergoes crisis at approximately passage 35 (CelloPub=CLPUB00738). Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations	Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (CelloPub=CLPUB00738; PubMed=9802058).
Disease	Anaplastic astrocytoma (NCIt: C9477) Anaplastic astrocytoma (ORDO: Orphanet_251589)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_C8E7 ! SJ-GBM4
Sex of cell	Female
Age at sampling	10Y
Category	Finite cell line
Publications	PubMed=8603418 Danks M.K., Garrett K.E., Marion R.C., Whipple D.O. Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan. Cancer Res. 56:1664-1673(1996) CLPUB00738 Nitiss K.C. Oncogenic changes and induction of differentiation in pediatric astrocytic cell lines. Thesis PhD (1997), University of Southern California Los Angeles, United States PubMed=9802058 McPake C.R., Tillman D.M., Poquette C.A., George E.O., Houghton J.A., Harris L.C. Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status. Oncol. Res. 10:235-244(1998) PubMed=10402232; DOI=10.3892/ijo.15.2.237 Sharif T.R., Sharif M. Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples. Int. J. Oncol. 15:237-243(1999)
Cell line databases/resources	cancercelllines; CVCL_A8SE
Encyclopedic resources	Wikidata; Q108821306
Polymorphism and mutation databases	IARC_TP53; 24987
Entry history
Entry creation	23-Sep-2021
Last entry update	05-Oct-2023
Version number	5