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Cellosaurus CLC12N2 (CVCL_A8GH)

[Text version]
Cell line name CLC12N2
Accession CVCL_A8GH
Resource Identification Initiative To cite this cell line use: CLC12N2 (RRID:CVCL_A8GH)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:16412; NLRC4 (Note=With p.Leu152_Ala1024del, CARD domain, C12N2 construct).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5331; NOD2 (Note=With p.Met1_Ala216del, NACHT+LRR domains, C12N2 construct).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Asn287Ser (c.860A>G); ClinVar=VCV000133954; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr103fs*37 (c.308_321delTGTGTAACAGTTCC); Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0218 (COLO 205)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): TKG=TKG 0802

Markers:
AmelogeninX
CSF1PO11,12
D5S81810,13
D7S8209,10
D13S31710,12
D16S53912,13
TH018,9
TPOX11
vWA15

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Publications

PubMed=20500518; DOI=10.1111/j.1349-7006.2010.01610.x; PMCID=PMC11159384
Motani K., Kawase K., Imamura R., Kinoshita T., Kushiyama H., Suda T.
Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication.
Cancer Sci. 101:1822-1827(2010)

Cross-references
Cell line collections (Providers) TKG; TKG 0802
Cell line databases/resources cancercelllines; CVCL_A8GH
Encyclopedic resources Wikidata; Q107114691
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number8