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Cellosaurus HepG2-R (CVCL_A8FT)

[Text version]
Cell line name HepG2-R
Accession CVCL_A8FT
Resource Identification Initiative To cite this cell line use: HepG2-R (RRID:CVCL_A8FT)
Comments Population: Caucasian.
Characteristics: Radioresistant. Can proliferate with daily exposure to 2 Gy X-rays for more than 30 days (PubMed=21716292).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): TKG=TKG 0799

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81811,12
D7S8209,10
D13S3179,13
D16S53912,13
TH019
TPOX8,9
vWA17

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Publications

PubMed=21716292; DOI=10.1038/cddis.2011.56; PMCID=PMC3168998
Kuwahara Y., Oikawa T., Ochiai Y., Roudkenar M.H., Fukumoto M., Shimura T., Ohtake Y., Ohkubo Y., Mori S., Uchiyama Y., Fukumoto M.
Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy.
Cell Death Dis. 2:e177.1-e177.11(2011)

PubMed=27681752; DOI=10.1016/j.ijrobp.2016.07.002
Kuwahara Y., Roudkenar M.H., Suzuki M., Urushihara Y., Fukumoto M., Saito Y., Fukumoto M.
The involvement of mitochondrial membrane potential in cross-resistance between radiation and docetaxel.
Int. J. Radiat. Oncol. Biol. Phys. 96:556-565(2016)

Cross-references
Cell line collections (Providers) TKG; TKG 0799
Cell line databases/resources cancercelllines; CVCL_A8FT
Encyclopedic resources Wikidata; Q107115339
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number7