Cellosaurus HEK-Blue IL-1beta (CVCL_A8CL)
| Cell line name | HEK-Blue IL-1beta | |
|---|---|---|
| Accession | CVCL_A8CL | |
| Resource Identification Initiative | To cite this cell line use: HEK-Blue IL-1beta (RRID:CVCL_A8CL) | |
| Comments | Characteristics: Designed to detect bioactive human and mouse IL1B monitoring the activation of the NF-kappaB and AP-1 pathways. In addition, the TNF-alpha, TLR3 and TLR5 responses have been blocked (InvivoGen). Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB and AP-1-binding sites. Knockout cell: Method=Not specified; HGNC; 11849; TLR3. Knockout cell: Method=Not specified; HGNC; 11851; TLR5. Knockout cell: Method=Not specified; HGNC; 11916; TNFRSF1A. Knockout cell: Method=Not specified; HGNC; 11917; TNFRSF1B. Genetic integration: Method=Transfection/transduction; Gene=HGNC; 439; ALPP. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Transformant: NCBI_TaxID; 28285; Adenovirus 5. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113. | |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | |
| Hierarchy | Parent: CVCL_A7YL (HEK-Blue Null1-v) Children:
| |
| Sex of cell | Female | |
| Age at sampling | Fetus | |
| Category | Transformed cell line | |
| Web pages | https://www.invivogen.com/hek-blue-il1b | |
| Cross-references | ||
| Encyclopedic resources | Wikidata; Q107115263 | |
| Entry history | ||
| Entry creation | 20-May-2021 | |
| Last entry update | 10-Sep-2024 | |
| Version number | 5 | |