Cellosaurus THP1-Blue KI-IP10 (CVCL_A8CC)
| Cell line name | THP1-Blue KI-IP10 |
|---|---|
| Synonyms | THP1-Blue KI-IP10-Lucia |
| Accession | CVCL_A8CC |
| Resource Identification Initiative | To cite this cell line use: THP1-Blue KI-IP10 (RRID:CVCL_A8CC) |
| Comments | Population: Japanese. Characteristics: The coding sequence of CXCL10 has been replaced with the Lucia luciferase reporter gene under the control of the endogenous promoter and thus allows the direct study of CXCL10 induction. Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 copies of the NF-kappaB consensus TRE and 3 copies of the c-Rel binding site. Knockout cell: Method=Not specified; HGNC; 10637; CXCL10. Genetic integration: Method=Transfection/transduction; Gene=HGNC; 439; ALPP. Genetic integration: Method=Transfection/transduction; Gene=Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; B.cereus Bsr. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
| Sequence variations |
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| Disease | Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_X585 (THP1-Blue NF-kappaB) |
| Sex of cell | Male |
| Age at sampling | 1Y |
| Category | Cancer cell line |
| Web pages | https://www.invivogen.com/thp1-blue-ki-ip10 |
| Cross-references | |
| Cell line databases/resources | cancercelllines; CVCL_A8CC |
| Encyclopedic resources | Wikidata; Q107117042 |
| Entry history | |
| Entry creation | 20-May-2021 |
| Last entry update | 10-Sep-2024 |
| Version number | 7 |