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Cellosaurus HepG2-Dual (CVCL_A8BS)

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Cell line name HepG2-Dual
Accession CVCL_A8BS
Resource Identification Initiative To cite this cell line use: HepG2-Dual (RRID:CVCL_A8BS)
Comments Population: Caucasian.
Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 c-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE).
Transfected with: HGNC; 439; ALPP.
Transfected with: Lucia luciferase, a synthetic gene designed on natural secreted luciferase genes from marine copepods.
Transfected with: UniProtKB; P33967; B.cereus Bsr.
Transfected with: UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Web pages https://www.invivogen.com/hepg2-dual
Cross-references
Cell line databases/resources cancercelllines; CVCL_A8BS
Encyclopedic resources Wikidata; Q107115334
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number7