Cellosaurus THP1-Dual KO-MDA5 (CVCL_A8BB)
| Cell line name | THP1-Dual KO-MDA5 |
|---|---|
| Accession | CVCL_A8BB |
| Resource Identification Initiative | To cite this cell line use: THP1-Dual KO-MDA5 (RRID:CVCL_A8BB) |
| Comments | Population: Japanese. Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE). Knockout cell: Method=Not specified; HGNC; HGNC:18873; IFIH1. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:439; ALPP. Genetic integration: Method=Transfection/transduction; Gene=Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; B.cereus Bsr. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
| Sequence variations |
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| Disease | Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_X599 (THP1-Dual) |
| Sex of cell | Male |
| Age at sampling | 1Y |
| Category | Cancer cell line |
| Web pages | https://www.invivogen.com/thp1-dual-ko-rlr |
| Cross-references | |
| Cell line databases/resources | cancercelllines; CVCL_A8BB |
| Encyclopedic resources | Wikidata; Q107117066 |
| Entry history | |
| Entry creation | 20-May-2021 |
| Last entry update | 19-Dec-2024 |
| Version number | 9 |