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Cellosaurus Jurkat-Lucia NFAT-CD16 (CVCL_A7ZT)

[Text version]
Cell line name Jurkat-Lucia NFAT-CD16
Accession CVCL_A7ZT
Resource Identification Initiative To cite this cell line use: Jurkat-Lucia NFAT-CD16 (RRID:CVCL_A7ZT)
Comments Population: Caucasian.
Characteristics: The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter fused to 6 NFAT consensus transcriptional response elements.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 3619; FCGR3A.
Genetic integration: Method=Transfection/transduction; Gene=Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_KS47 (Jurkat-Lucia NFAT)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Web pages https://www.invivogen.com/jurkat-lucia-nfat-adcc-adcp-cells
Cross-references
Cell line databases/resources cancercelllines; CVCL_A7ZT
Encyclopedic resources Wikidata; Q107115511
Entry history
Entry creation20-May-2021
Last entry update10-Sep-2024
Version number7