ID   2XSB
AC   CVCL_A7NI
DR   cancercelllines; CVCL_A7NI
DR   Wikidata; Q107117558
RX   PubMed=33707600;
CC   Population: Caucasian.
CC   Doubling time: 28.0 +- 3.09 hours (Note=At 6th passage), 27.3 +- 4.06 hours (Note=At 54th passage) (PubMed=33707600).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=33707600).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=33707600).
CC   Sequence variation: Mutation; HGNC; HGNC:19291; CSMD3; Simple; p.Trp3337Ter (c.10010G>A); Zygosity=Heterozygous (PubMed=33707600).
CC   Sequence variation: Mutation; HGNC; HGNC:2976; DNMT1; Simple; c.2586+1G>A; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=33707600).
CC   Sequence variation: Mutation; HGNC; HGNC:6697; LRP5; Simple; p.Arg428Ter (c.1282C>T); ClinVar=VCV000006269; Zygosity=Heterozygous (PubMed=33707600).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; None_reported; -; Zygosity=- (PubMed=33707600).
CC   Sequence variation: Mutation; HGNC; HGNC:8059; NUMA1; Simple; p.Leu1167Alafs*39 (c.3499_3500delCT); Zygosity=Heterozygous (PubMed=33707600).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Pro38Ser (c.112C>T); ClinVar=VCV000127688; Zygosity=Homozygous (PubMed=33707600).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His178Asp (c.532C>G); ClinVar=VCV000482223; Zygosity=Homozygous (PubMed=33707600).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Misspelling: X2SB; Note=In Cellosaurus release 38.
CC   Derived from site: In situ; Right brachial nerve; UBERON=UBERON_0001814.
ST   Source(s): PubMed=33707600
ST   Amelogenin: X
ST   CSF1PO: 15
ST   D13S317: 8
ST   D16S539: 11
ST   D18S51: 15
ST   D19S433: 14,15.2
ST   D21S11: 30,30.2
ST   D2S1338: 17,26
ST   D3S1358: 16
ST   D5S818: 11
ST   D7S820: 8,9
ST   D8S1179: 11,13
ST   FGA: 19,23
ST   TH01: 7,9.3
ST   TPOX: 11,12
ST   vWA: 17,18
DI   NCIt; C3798; Malignant peripheral nerve sheath tumor
DI   ORDO; Orphanet_3148; Malignant peripheral nerve sheath tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   57Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 19-12-24; Version: 6
//
RX   PubMed=33707600; DOI=10.1038/s41598-021-85055-2; PMCID=PMC7952412;
RA   Longo J.F., Brosius S.N., Znoyko I., Alers V.A., Jenkins D.P.,
RA   Wilson R.C., Carroll A.J. 3rd, Wolff D.J., Roth K.A., Carroll S.L.;
RT   "Establishment and genomic characterization of a sporadic malignant
RT   peripheral nerve sheath tumor cell line.";
RL   Sci. Rep. 11:5690-5690(2021).
//