Cellosaurus cell line MEF_Hsp47 WT-1 (CVCL

Cross-references
Cell line name	MEF_Hsp47 WT-1
Accession	CVCL_A7BC
Resource Identification Initiative	To cite this cell line use: MEF_Hsp47 WT-1 (RRID:CVCL_A7BC)
Comments	Characteristics: Control cell line for MEF_Hsp47 KO-11 (Cellosaurus=CVCL_A7BD) and MEF_Hsp47 KO-13 (Cellosaurus=CVCL_A7BE). Derived from site: In situ; Embryo; UBERON=UBERON_0000922. Cell type: Fibroblast; CL=CL_0000057.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Sex of cell	Sex unspecified
Age at sampling	8-9FD
Category	Spontaneously immortalized cell line
Publications	PubMed=10995453; DOI=10.1083/jcb.150.6.1499; PMCID=PMC2150697 Nagai N., Hosokawa M., Itohara S., Adachi E., Matsushita T., Hosokawa N., Nagata K. Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis. J. Cell Biol. 150:1499-1506(2000) PubMed=16525016; DOI=10.1091/mbc.e05-11-1065; PMCID=PMC1446091 Ishida Y., Kubota H., Yamamoto A., Kitamura A., Bachinger H.P., Nagata K. Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis. Mol. Biol. Cell 17:2346-2355(2006)
Cell line collections (Providers)	RCB; RCB5291
Encyclopedic resources	Wikidata; Q107116343
Entry history
Entry creation	20-May-2021
Last entry update	29-Jun-2023
Version number	6