ID   SCL-I
AC   CVCL_A789
SY   SCL I; SCL-1; SCL1
DR   ChEMBL-Cells; CHEMBL3307442
DR   ChEMBL-Targets; CHEMBL614903
DR   CLS; 300496
DR   Cosmic; 740987
DR   PubChem_Cell_line; CVCL_A789
DR   Wikidata; Q54952439
RX   PubMed=2293663;
RX   PubMed=6196111;
RX   PubMed=6950169;
RX   PubMed=11992403;
CC   Population: Caucasian.
CC   Doubling time: ~50-60 hours (CLS=300496).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val197Ter; Zygosity=Unspecified (PubMed=11992403).
CC   Derived from site: In situ; Face, skin; UBERON=UBERON_1000021.
ST   Source(s): CLS=300496
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 9,11
ST   D16S539: 9,12
ST   D18S51: 16,19
ST   D21S11: 29,30
ST   D3S1358: 16,17
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 13,14
ST   FGA: 21
ST   Penta D: 13,14
ST   Penta E: 12
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 16,18
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   74Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 17
//
RX   PubMed=2293663; DOI=10.1128/JVI.64.1.215-221.1990; PMCID=PMC249089;
RA   Chesebro B.W., Buller R., Portis J.L., Wehrly K.;
RT   "Failure of human immunodeficiency virus entry and infection in
RT   CD4-positive human brain and skin cells.";
RL   J. Virol. 64:215-221(1990).
//
RX   PubMed=6196111;
RA   Tilgen W., Boukamp P., Breitkreutz D., Dzarlieva-Petrusevska R.T.,
RA   Engstner M., Haag D., Fusenig N.E.;
RT   "Preservation of morphological, functional, and karyotypic traits
RT   during long-term culture and in vivo passage of two human skin
RT   squamous cell carcinomas.";
RL   Cancer Res. 43:5995-6011(1983).
//
RX   PubMed=6950169; DOI=10.1093/jnci/68.3.415;
RA   Boukamp P., Tilgen W., Dzarlieva-Petrusevska R.T., Breitkreutz D.,
RA   Haag D., Riehl R.K., Bohnert A., Fusenig N.E.;
RT   "Phenotypic and genotypic characteristics of a cell line from a
RT   squamous cell carcinoma of human skin.";
RL   J. Natl. Cancer Inst. 68:415-427(1982).
//
RX   PubMed=11992403; DOI=10.1002/ijc.10321;
RA   Popp S., Waltering S., Herbst C., Moll I., Boukamp P.;
RT   "UV-B-type mutations and chromosomal imbalances indicate common
RT   pathways for the development of Merkel and skin squamous cell
RT   carcinomas.";
RL   Int. J. Cancer 99:352-360(2002).
//