ID   NCI-N231
AC   CVCL_A788
SY   NCI-N-231; N231; N-231; NCI-H231; H231
DR   EFO; EFO_0002840
DR   cancercelllines; CVCL_A788
DR   Cosmic; 844811
DR   Cosmic; 918015
DR   Cosmic; 929979
DR   Cosmic; 953989
DR   IARC_TP53; 11868
DR   Wikidata; Q54908208
RX   PubMed=1847845;
RX   PubMed=2540905;
RX   PubMed=2985257;
RX   PubMed=6108156;
RX   PubMed=6270685;
RX   PubMed=6272398;
RX   PubMed=6713399;
RX   PubMed=8806092;
RX   PubMed=10536175;
RX   PubMed=12569360;
CC   Characteristics: Established from a mouse xenograft.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Unspecified (PubMed=10536175).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 30-01-24; Version: 18
//
RX   PubMed=1847845; DOI=10.1007/BF00685110;
RA   Sasaki Y., Shinkai T., Eguchi K., Tamura T., Ohe Y., Ohmori T.,
RA   Saijo N.;
RT   "Prediction of the antitumor activity of new platinum analogs based on
RT   their ex vivo pharmacodynamics as determined by bioassay.";
RL   Cancer Chemother. Pharmacol. 27:263-270(1991).
//
RX   PubMed=2540905;
RA   Takahashi T., Obata Y., Sekido Y., Hida T., Ueda R., Watanabe H.,
RA   Ariyoshi Y., Sugiura T., Takahashi T.;
RT   "Expression and amplification of myc gene family in small cell lung
RT   cancer and its relation to biological characteristics.";
RL   Cancer Res. 49:2683-2688(1989).
//
RX   PubMed=2985257;
RA   Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J.,
RA   Moody T.W., Zweig M.H., Minna J.D.;
RT   "Establishment and identification of small cell lung cancer cell lines
RT   having classic and variant features.";
RL   Cancer Res. 45:2913-2923(1985).
//
RX   PubMed=6108156;
RA   Gazdar A.F., Carney D.N., Russell E.K., Sims H.L., Baylin S.B.,
RA   Bunn P.A. Jr., Guccion J.G., Minna J.D.;
RT   "Establishment of continuous, clonable cultures of small-cell
RT   carcinoma of lung which have amine precursor uptake and
RT   decarboxylation cell properties.";
RL   Cancer Res. 40:3502-3507(1980).
//
RX   PubMed=6270685; DOI=10.1073/pnas.78.7.4591;
RA   Cuttitta F., Rosen S.T., Gazdar A.F., Minna J.D.;
RT   "Monoclonal antibodies that demonstrate specificity for several types
RT   of human lung cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981).
//
RX   PubMed=6272398; DOI=10.1126/science.6272398;
RA   Moody T.W., Pert C.B., Gazdar A.F., Carney D.N., Minna J.D.;
RT   "High levels of intracellular bombesin characterize human small-cell
RT   lung carcinoma.";
RL   Science 214:1246-1248(1981).
//
RX   PubMed=6713399;
RA   Rosen S.T., Mulshine J.L., Cuttitta F., Fedorko J., Carney D.N.,
RA   Gazdar A.F., Minna J.D.;
RT   "Analysis of human small cell lung cancer differentiation antigens
RT   using a panel of rat monoclonal antibodies.";
RL   Cancer Res. 44:2052-2061(1984).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=12569360; DOI=10.1038/sj.onc.1206106;
RA   Funakoshi T., Tachibana I., Hoshida Y., Kimura H., Takeda Y.,
RA   Kijima T., Nishino K., Goto H., Yoneda T., Kumagai T., Osaki T.,
RA   Hayashi S., Aozasa K., Kawase I.;
RT   "Expression of tetraspanins in human lung cancer cells: frequent
RT   downregulation of CD9 and its contribution to cell motility in small
RT   cell lung cancer.";
RL   Oncogene 22:674-687(2003).
//