ID   YUSAC2
AC   CVCL_A746
SY   YUSAC-2; YUSAC 2; YUSAC
DR   cancercelllines; CVCL_A746
DR   Cosmic; 1197388
DR   Wikidata; Q54995793
RX   PubMed=9177196;
RX   PubMed=20149136;
RX   PubMed=21569352;
RX   PubMed=23012583;
CC   Part of: Yale University (YU) melanoma cell collection.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=20149136).
CC   Derived from site: Metastatic; Neck, hypodermis; UBERON=UBERON_0000974+UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 16
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RX   PubMed=9177196; DOI=10.1073/pnas.94.12.6210;
RA   Halaban R., Cheng E., Zhang Y., Moellmann G.E., Hanlon D., Michalak M.,
RA   Setaluri V., Hebert D.N.;
RT   "Aberrant retention of tyrosinase in the endoplasmic reticulum
RT   mediates accelerated degradation of the enzyme and contributes to the
RT   dedifferentiated phenotype of amelanotic melanoma cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:6210-6215(1997).
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RX   PubMed=20149136; DOI=10.1111/j.1755-148X.2010.00685.x;
RA   Halaban R., Zhang W., Bacchiocchi A., Cheng E., Parisi F., Ariyan S.,
RA   Krauthammer M., McCusker J.P., Kluger Y., Sznol M.;
RT   "PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK
RT   pathway and enhances cell migration and proliferation of BRAF melanoma
RT   cells.";
RL   Pigment Cell Melanoma Res. 23:190-200(2010).
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RX   PubMed=21569352; DOI=10.1186/1471-2164-12-230;
RA   Parisi F., Ariyan S., Narayan D., Bacchiocchi A., Hoyt K., Cheng E.,
RA   Xu F., Li P.-N., Halaban R., Kluger Y.;
RT   "Detecting copy number status and uncovering subclonal markers in
RT   heterogeneous tumor biopsies.";
RL   BMC Genomics 12:230.1-230.14(2011).
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RX   PubMed=23012583;
RA   Parisi F., Micsinai M., Strino F., Ariyan S., Narayan D.,
RA   Bacchiocchi A., Cheng E., Xu F., Li P.-N., Kluger H.M., Halaban R.,
RA   Kluger Y.;
RT   "Integrated analysis of tumor samples sheds light on tumor
RT   heterogeneity.";
RL   Yale J. Biol. Med. 85:347-361(2012).
//