ID   YUGEN8
AC   CVCL_A744
SY   YUGEN-8; YUGEN 8
DR   cancercelllines; CVCL_A744
DR   Cosmic; 1197387
DR   Cosmic; 1548855
DR   Cosmic; 2439320
DR   Wikidata; Q54995662
RX   PubMed=9177196;
RX   PubMed=20149136;
RX   PubMed=21543894;
RX   PubMed=21569352;
RX   PubMed=23012583;
RX   PubMed=26214590;
CC   Part of: Yale University (YU) melanoma cell collection.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=20149136; PubMed=26214590).
CC   Omics: Deep exome analysis.
CC   Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 18
//
RX   PubMed=9177196; DOI=10.1073/pnas.94.12.6210;
RA   Halaban R., Cheng E., Zhang Y., Moellmann G.E., Hanlon D., Michalak M.,
RA   Setaluri V., Hebert D.N.;
RT   "Aberrant retention of tyrosinase in the endoplasmic reticulum
RT   mediates accelerated degradation of the enzyme and contributes to the
RT   dedifferentiated phenotype of amelanotic melanoma cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:6210-6215(1997).
//
RX   PubMed=20149136; DOI=10.1111/j.1755-148X.2010.00685.x;
RA   Halaban R., Zhang W., Bacchiocchi A., Cheng E., Parisi F., Ariyan S.,
RA   Krauthammer M., McCusker J.P., Kluger Y., Sznol M.;
RT   "PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK
RT   pathway and enhances cell migration and proliferation of BRAF melanoma
RT   cells.";
RL   Pigment Cell Melanoma Res. 23:190-200(2010).
//
RX   PubMed=21543894; DOI=10.4161/cc.10.11.15777;
RA   Chan E., Patel R., Nallur S., Ratner E., Bacchiocchi A., Hoyt K.,
RA   Szpakowski S., Godshalk S., Ariyan S., Sznol M., Halaban R.,
RA   Krauthammer M., Tuck D., Slack F.J., Weidhaas J.B.;
RT   "MicroRNA signatures differentiate melanoma subtypes.";
RL   Cell Cycle 10:1845-1852(2011).
//
RX   PubMed=21569352; DOI=10.1186/1471-2164-12-230;
RA   Parisi F., Ariyan S., Narayan D., Bacchiocchi A., Hoyt K., Cheng E.,
RA   Xu F., Li P.-N., Halaban R., Kluger Y.;
RT   "Detecting copy number status and uncovering subclonal markers in
RT   heterogeneous tumor biopsies.";
RL   BMC Genomics 12:230.1-230.14(2011).
//
RX   PubMed=23012583;
RA   Parisi F., Micsinai M., Strino F., Ariyan S., Narayan D.,
RA   Bacchiocchi A., Cheng E., Xu F., Li P.-N., Kluger H.M., Halaban R.,
RA   Kluger Y.;
RT   "Integrated analysis of tumor samples sheds light on tumor
RT   heterogeneity.";
RL   Yale J. Biol. Med. 85:347-361(2012).
//
RX   PubMed=26214590; DOI=10.1038/ng.3361;
RA   Krauthammer M., Kong Y., Bacchiocchi A., Evans P., Pornputtapong N.,
RA   Wu C., McCusker J.P., Ma S.-G., Cheng E., Straub R., Serin M.,
RA   Bosenberg M.W., Ariyan S., Narayan D., Sznol M., Kluger H.M., Mane S.,
RA   Schlessinger J., Lifton R.P., Halaban R.;
RT   "Exome sequencing identifies recurrent mutations in NF1 and RASopathy
RT   genes in sun-exposed melanomas.";
RL   Nat. Genet. 47:996-1002(2015).
//