ID   UKRV-Mel-19a
AC   CVCL_A720
DR   cancercelllines; CVCL_A720
DR   Cosmic; 906464
DR   Cosmic; 1846707
DR   Cosmic; 2686520
DR   Wikidata; Q54990605
RX   PubMed=10594685;
RX   PubMed=15760917;
RX   PubMed=23348503;
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-149C>T (c.253C>T) (C253T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_C399 ! UKRV-Mel-19b
OI   CVCL_C400 ! UKRV-Mel-19c
SX   Female
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 14
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RX   PubMed=10594685; DOI=10.1046/j.1365-2567.1999.00902.x; PMCID=PMC2326956;
RA   Sun Y.-S., Moller P., Berking C., Schlupen E.-M., Volkenandt M.,
RA   Schadendorf D.;
RT   "In vivo selective expansion of a tumour-specific cytotoxic T-cell
RT   clone derived from peripheral blood of a melanoma patient after
RT   vaccination with gene-modified autologous tumour cells.";
RL   Immunology 98:535-540(1999).
//
RX   PubMed=15760917; DOI=10.1093/carcin/bgi066;
RA   Bloethner S., Chen B.-W., Hemminki K., Mueller-Berghaus J., Ugurel S.,
RA   Schadendorf D., Kumar R.;
RT   "Effect of common B-RAF and N-RAS mutations on global gene expression
RT   in melanoma cell lines.";
RL   Carcinogenesis 26:1224-1232(2005).
//
RX   PubMed=23348503; DOI=10.1126/science.1230062;
RA   Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A.,
RA   Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.;
RT   "TERT promoter mutations in familial and sporadic melanoma.";
RL   Science 339:959-961(2013).
//