ID   UKRV-Mel-17
AC   CVCL_A716
DR   cancercelllines; CVCL_A716
DR   Cosmic; 2163837
DR   Cosmic; 2686519
DR   ECACC; 13012514
DR   ESTDAB; ESTDAB-147
DR   Wikidata; Q54990600
RX   PubMed=10594685;
RX   PubMed=15592718;
RX   PubMed=17311103;
RX   PubMed=23348503;
RX   PubMed=23851445;
CC   HLA typing: A*01:01,03:01; B*15:01:01:01,57:01:01; C*06:02,03:04; DPB1*04:01; DQB1*03:02,02:01; DRB1*04:01,03:01:01 (PubMed=15592718).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17311103; PubMed=23348503; PubMed=23851445).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): ECACC=13012514; ESTDAB=ESTDAB-147
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 10,13
ST   D3S1358: 14,16
ST   D5S818: 11,12
ST   D7S820: 8
ST   FGA: 21,24
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 15,16
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 23
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RX   PubMed=10594685; DOI=10.1046/j.1365-2567.1999.00902.x; PMCID=PMC2326956;
RA   Sun Y.-S., Moller P., Berking C., Schlupen E.-M., Volkenandt M.,
RA   Schadendorf D.;
RT   "In vivo selective expansion of a tumour-specific cytotoxic T-cell
RT   clone derived from peripheral blood of a melanoma patient after
RT   vaccination with gene-modified autologous tumour cells.";
RL   Immunology 98:535-540(1999).
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A.,
RA   Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G.,
RA   Garrido F.;
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595;
RA   Ugurel S., Thirumaran R.K., Bloethner S., Gast A., Sucker A.,
RA   Mueller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R.,
RA   Schadendorf D.;
RT   "B-RAF and N-RAS mutations are preserved during short time in vitro
RT   propagation and differentially impact prognosis.";
RL   PLoS ONE 2:E236-E236(2007).
//
RX   PubMed=23348503; DOI=10.1126/science.1230062;
RA   Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A.,
RA   Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.;
RT   "TERT promoter mutations in familial and sporadic melanoma.";
RL   Science 339:959-961(2013).
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RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L.,
RA   Borg A., Pawelec G., Guldberg P.;
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//