ID   COLO 320DM#3 SIRT1 KO cl.6
AC   CVCL_A6UQ
SY   COLO 320DM#3 SIRT1 KO clone 6
DR   cancercelllines; CVCL_A6UQ
DR   RCB; RCB5386
DR   Wikidata; Q107114701
RX   PubMed=33539925;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 14929; SIRT1.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Ser811Ter (c.2432C>G); ClinVar=VCV002203685; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0219 ! COLO 320DM
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 5
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RX   PubMed=33539925; DOI=10.1016/j.jbc.2021.100356; PMCID=PMC7949162;
RA   Taniguchi R., Utani K., Thakur B., Ishine K., Aladjem M.I.,
RA   Shimizu N.;
RT   "SIRT1 stabilizes extrachromosomal gene amplification and contributes
RT   to repeat-induced gene silencing.";
RL   J. Biol. Chem. 296:100356.1-100356.12(2021).
//