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Cellosaurus COLO 320DM#3 SIRT1 KO cl.5 (CVCL_A6UP)

[Text version]
Cell line name COLO 320DM#3 SIRT1 KO cl.5
Synonyms COLO 320DM#3 SIRT1 KO clone 5
Accession CVCL_A6UP
Resource Identification Initiative To cite this cell line use: COLO 320DM#3 SIRT1 KO cl.5 (RRID:CVCL_A6UP)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14929; SIRT1.
Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Ser811Ter (c.2432C>G); ClinVar=VCV002203685; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0219 (COLO 320DM)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=33539925; DOI=10.1016/j.jbc.2021.100356; PMCID=PMC7949162
Taniguchi R., Utani K., Thakur B., Ishine K., Aladjem M.I., Shimizu N.
SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing.
J. Biol. Chem. 296:100356.1-100356.12(2021)

Cross-references
Cell line collections (Providers) RCB; RCB5385
Cell line databases/resources cancercelllines; CVCL_A6UP
Encyclopedic resources Wikidata; Q107114700
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number6