ID   COLO 320DM#3
AC   CVCL_A6UJ
SY   COLO 320DM #3; COLO 320 (DM) subclone 3
DR   cancercelllines; CVCL_A6UJ
DR   Wikidata; Q107114695
RX   PubMed=3164477;
RX   PubMed=31569279;
RX   PubMed=33539925;
CC   Population: Caucasian.
CC   Characteristics: Contains multiple DMs with amplified MYC (PubMed=3164477).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Ser811Ter (c.2432C>G); ClinVar=VCV002203685; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0219 ! COLO 320DM
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 5
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RX   PubMed=3164477; DOI=10.1073/pnas.85.13.4804;
RA   Von Hoff D.D., Needham-VanDevanter D.R., Yucel J., Windle B.E.,
RA   Wahl G.M.;
RT   "Amplified human MYC oncogenes localized to replicating submicroscopic
RT   circular DNA molecules.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:4804-4808(1988).
//
RX   PubMed=31569279; DOI=10.1002/gcc.22810;
RA   Oobatake Y., Shimizu N.;
RT   "Double-strand breakage in the extrachromosomal double minutes
RT   triggers their aggregation in the nucleus, micronucleation, and
RT   morphological transformation.";
RL   Genes Chromosomes Cancer 59:133-143(2020).
//
RX   PubMed=33539925; DOI=10.1016/j.jbc.2021.100356;
RA   Taniguchi R., Utani K., Thakur B., Ishine K., Aladjem M.I.,
RA   Shimizu N.;
RT   "SIRT1 stabilizes extrachromosomal gene amplification and contributes
RT   to repeat-induced gene silencing.";
RL   J. Biol. Chem. 296:100356.1-100356.12(2021).
//