Cellosaurus cell line 22Rv1-CabR2 (CVCL

Cellosaurus 22Rv1-CabR2 (CVCL_A6PH)

Cross-references
Cell line name	22Rv1-CabR2
Accession	CVCL_A6PH
Resource Identification Initiative	To cite this cell line use: 22Rv1-CabR2 (RRID:CVCL_A6PH)
Comments	Population: Caucasian. Characteristics: Established from xenografts that were obtain by subcutaneously injecting 22Rv1 cells into the flanks of 8 weeks old, athymic male BALB/c nude mice and treating them with cabazitaxel (PubMed=31799745). Selected for resistance to: ChEBI; CHEBI:63584; Cabazitaxel. Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations	Mutation; HGNC; 1097; BRAF; Simple; p.Leu597Arg (c.1790T>G); ClinVar=VCV000013968; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 7133; KMT2D; Simple; p.Gln3158Ter (c.9472C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 8975; PIK3CA; Simple; p.Gln546Arg (c.1637A>G); ClinVar=VCV000045466; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Heterozygous (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1045 (22Rv1)
Sex of cell	Male
Age at sampling	Adult
Category	Cancer cell line
Publications	PubMed=31799745; DOI=10.1002/pros.23935; PMCID=PMC6973163 Ylitalo E.B., Thysell E., Thellenberg-Karlsson C., Lundholm M., Widmark A., Bergh A., Josefsson A., Brattsand M., Wikstrom P. Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti-androgens. Prostate 80:214-224(2020)
Cell line databases/resources	cancercelllines; CVCL_A6PH
Encyclopedic resources	Wikidata; Q107113179
Entry history
Entry creation	20-May-2021
Last entry update	10-Sep-2024
Version number	6