Cellosaurus cell line 182-D1106-362 (CVCL

Cellosaurus 182-D1106-362 (CVCL_A6LD)

Cross-references
Cell line name	182-D1106-362
Synonyms	175D10
Accession	CVCL_A6LD
Resource Identification Initiative	To cite this cell line use: 182-D1106-362 (RRID:CVCL_A6LD)
Comments	Group: Patented cell line. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2810. Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized IMAB362 (claudiximab; zolbetuximab) therapeutic antibody. Monoclonal antibody isotype: IgG1, kappa. Monoclonal antibody target: UniProtKB; P56856; Human CLDN18 (Note=Isoform A2 = CLDN18.2).
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy	Parent: CVCL_3412 (P3X63Ag8U.1)
Category	Hybridoma
Publications	PubMed=19047087; DOI=10.1158/1078-0432.CCR-08-1547 Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tureci O. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. Clin. Cancer Res. 14:7624-7634(2008) Patent=US10314890 Sahin U., Tureci O., Mitnacht-Kraus R., Woll S., Jacobs S., Heinz C. Combination therapy involving antibodies against claudin 18.2 for treatment of cancer. Patent number US10314890, 11-Jun-2019 Patent=US10738108 Sahin U., Tureci O., Usener D., Fritz S., Uherek C., Brandenburg G., Geppert H.-G., Schroder A.K., Thiel P. Monoclonal antibodies against claudin-18 for treatment of cancer. Patent number US10738108, 11-Aug-2020
Encyclopedic resources	Wikidata; Q107113149
Entry history
Entry creation	20-May-2021
Last entry update	10-Sep-2024
Version number	6