Cell line name |
A4H12 |
Accession |
CVCL_A6KJ |
Resource Identification Initiative |
To cite this cell line use: A4H12 (RRID:CVCL_A6KJ) |
Comments |
Group: Hybridoma fusion partner cell line. Population: Caucasian. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult T acute lymphoblastic leukemia (NCIt: C9142) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0013 (MOLT-4) Children:
|
Sex of cell |
Male |
Age at sampling |
19Y |
Category |
Cancer cell line |
Publications | PubMed=1368811; DOI=10.1007/BF02525493 Kuroita T., Tachibana H., Ohashi H., Shirahata S., Murakami H. Growth stimulating activity of heat shock protein 90 alpha to lymphoid cell lines in serum-free medium. Cytotechnology 8:109-117(1992) PubMed=1576323; DOI=10.3233/HAB-1992-3102 Kawahara H., Shirahata S., Tachibana H., Murakami H. In vitro immunization of human lymphocytes with human lung cancer cell line A549. Hum. Antibodies Hybridomas 3:8-13(1992) DOI=10.1007/978-94-011-2044-9_87 Seki K., Kawahara H., Sato S., Tachibana H., Kido I., Hashimoto A., Hashizume S., Murakami H. Reactivity of human monoclonal antibody BD9-D12 to cancer cells and tissues. (In book chapter) Animal cell technology. Basic and applied aspects, Vol. 5; Kaminogawa S., Ametani A., Hachimura S. (eds.); pp.647-652; Springer; Dordrecht; Netherlands (1993) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_A6KJ
|
Encyclopedic resources |
Wikidata; Q107113322
|
Entry history |
Entry creation | 20-May-2021 |
Last entry update | 05-Oct-2023 |
Version number | 7 |
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