ID   WIL2 MTI-TG
AC   CVCL_A6HS
SY   MTI-TG
DR   Wikidata; Q107117458
RX   PubMed=197600;
RX   PubMed=893394;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:44081; 6-methylthioinosine (6-methylmercaptopurine riboside).
CC   Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
CC   Sequence variation: Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
CC   Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A6HR ! WIL2 MTIr-107
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 29-06-23; Version: 4
//
RX   PubMed=197600; DOI=10.1126/science.197600;
RA   Hershfield M.S., Snyder F.F., Seegmiller J.E.;
RT   "Adenine and adenosine are toxic to human lymphoblast mutants
RT   defective in purine salvage enzymes.";
RL   Science 197:1284-1287(1977).
//
RX   PubMed=893394; DOI=10.1016/S0021-9258(17)40020-2;
RA   Hershfield M.S., Seegmiller J.E.;
RT   "Regulation of de novo purine synthesis in human lymphoblasts. Similar
RT   rates of de novo synthesis during growth by normal cells and mutants
RT   deficient in hypoxanthine-guanine phosphoribosyltransferase
RT   activity.";
RL   J. Biol. Chem. 252:6002-6010(1977).
//